The background of the game is based on Los Angeles and Southern California. The game has almost the same world outlook as the real world. Players can play three protagonists and switch at any time (they can't switch when they do some tasks or when they are wanted). Each protagonist has his own unique personality, story background and interwoven plot.

Multiplayer online mode timeline after the end of story mode, Trev appears as NPC, and Mike can also meet as a passer-by in the game. The following plot will continue according to the story line of the third way of C ending.

In March 2021, the weekly sales list of steam game platform (March 15 to March 21) shows that gta5 is back on the list